Boston Children's Hospital

Recognized as Center of Excellence on 9/16/2017, Public Announcement

Phone: (617) 919-1379

Address: 300 Longwood Ave, Boston MA 02115

Number of CCM outpatient appointments annually: ~50

Number of CCM inpatient days annually: ~110

Number of CCM research publications 2012-2017: 17

Patients may also be seen at Boston Children's at Waltham, Boston Children's at Peabody, and Boston Children's at Dartmouth.


Medical Director and Pediatric Cerebrovascular Neurosurgeon: Edward Smith, MD

Pediatric Neurologist: Michael Rivkin, MD,  Laura Lehman. MD

Pediatric Epileptologist: Phillip Pearl, MD

Geneticist: Siddharth Srivastava, MD

Neurointerventional Radiologist: Darren Orbach, MD

Researcher: Mustafa Sahin, MD, Ph.D.

Nurse Coordinator: Jennifer Klein, MSN-FNP

Summary of Boston Children's Hospital Research Program

Boston Children’s Hospital has been actively engaged in clinical and translational research related to cavernous malformations.  The hospital encompasses the Vascular Biology Program (VBP), headed by Dr. Marsha Moses, one of the largest basic and translational research programs in the world focused on vascular disease. There are ongoing protocols for patient-derived cell lines for therapeutic targeting (DFCI 10-417), small molecule drug delivery targeting and urinary biomarker screening (AS 10-076-7) translational work.  There are numerous basic studies, primarily done in the VBP looking at endothelial cell biology and migration.  Lastly, there are several ongoing clinical studies, including a long-term follow-up and outcomes study (CR 127-54-2) for pediatric cavernous malformations.  

Patient Education includes a dedicated web page for CCM, a nurse hotline, and patient lectures at BCH in Boston.

Medical Provider Education includes Grand Rounds and incorporation of CCM in medical school training.