Research & Clinical Trials

Cavernous angioma research is an active area where scientists are working to fully understand the biology of the disease. Some do this by focusing on laboratory studies with molecules, cells, or animals. Researchers have also begun to include humans in studies, which is known as clinical research. These clinical studies can help us understand how the illness affects people over time (natural history studies) or can assign volunteers to groups that receive health-related interventions to compare their effectiveness (clinical trials). These research studies require human participants like you.

The menu will direct you to more information related to a variety of research topics including study participation, information about the progress of treatments under development, breaking news, and an overview of active research studies around the world.

The flowchart below is a tool designed to help identify studies for which you may be interested and eligible to participate.

Everyone with a cavernous angioma in the brain or spinal cord can join the Angioma Alliance Cavernous Angioma Registry to receive personalized notifications about new research and to add to our understanding of the illness. Registering takes only 20 minutes.

Last updated 6.15.20

Research participation flowchart

Title: Tool to help identify studies you may be interested in and eligible for.

Options for participating in research

Option 1: Clinical Drug Trials

Can you answer YES to the following 3 questions?
Question 1: Have you experienced hemorrhage with the last 12 months?
Question 2: Have you been treated with a statin drug within the last 12 months?
Question 3: Are you willing to travel to the University of Chicago 3 times over the next 2 years?
If you answered YES to all three questions, you may be eligible for the Atorvastatin Trial.
If you answered NO to any of the three questions, please see Option 2.

Option 2: Research Studies

Question 1: Have you had a recent or upcoming surgical resection?
If YES, you may look into the DNA/Tissue Bank.
If NO, go on to Question 2.

Question 2: Have you experienced hemorrhage within the last 12 months?
If YES, you may look into the CASH Trial Readiness Project.
If no, go on to Question 3.

Question 3: Does cavernous angioma run in your family?
If YES, you may look into the BVMC and/or Microbiome Study.
If NO, you may join the International Cavernous Angioma Registry.
If you don’t know, you may want to learn more about sporadic cavernous angioma.